abstract：:Electrical field stimulation (EFS, 2.5 Hz, 60 V, 1 ms, trains of 5 sec every 5 min) of the rat external urethral sphincter (EUS) produced contractile responses characterized by a "slow" tonic contraction on which was superimposed a series of phasic "twitch-like" contractions. Both responses were abolished by tetrodoto...

journal_title：Journal of pharmacological and toxicological methods

authors： Parlani M,Manzini S,Argentino-Storino A,Conte B

更新日期：1992-09-01 00:00:00

abstract：:Escherichia coli produces a heat-stable (STa) enterotoxin that belongs to a family of peptides that mediate several diarrheal diseases, including traveler's diarrhea and epidemic diarrhea in infants and newborns. The STa enterotoxin consists of 18 or 19 amino acids and is encoded by genes specified on a transposon. In...

journal_title：Journal of pharmacological and toxicological methods

authors： Knoop FC,Owens M

更新日期：1992-09-01 00:00:00

abstract：:A review of numerous studies of the protein binding of vancomycin suggests major discrepancies among their results. The reported percent protein binding of vancomycin varies from 0% to 98%. The influence of pH and concentration on the protein binding of vancomycin was investigated in this study. There was a significan...

journal_title：Journal of pharmacological and toxicological methods

authors： Chen Y,Norris RL,Schneider JJ,Ravenscroft PJ

更新日期：1992-08-01 00:00:00

abstract：:The use of 3H-paroxetine as a ligand for quantitative autoradiography of serotonin (5-HT) transport sites was optimized, and the distribution of 3H-paroxetine binding sites in rat brain was studied. Under the conditions described, 3H-paroxetine binding in forebrain sections was of high affinity and saturable, with a K...

journal_title：Journal of pharmacological and toxicological methods

authors： Chen HT,Clark M,Goldman D

更新日期：1992-07-01 00:00:00

abstract：:The purpose of this study was to develop a simple and noninvasive method for the quantitative evaluation of neuromuscular blockade in mice. The sciatic nerve in anesthetized animals (etomidate, 50 mg/kg or mephenesin, 250 mg/kg) was stimulated using transcutaneous electrodes; repetitive supramaximal stimulations (3 Hz...

journal_title：Journal of pharmacological and toxicological methods

authors： Lefebvre HP,Cardona A,Toutain PL,Morel E,Bach JF,Vernet-der-Garabedian B

更新日期：1992-05-01 00:00:00

abstract：:Regulation of brain temperature during and after cerebral ischemia plays an important role in the evolution of neuronal damage. Therefore, it is essential to maintain brain temperature at 37 degrees C during and after the ischemic insult. To get information about brain temperature during the experimental procedure, re...

journal_title：Journal of pharmacological and toxicological methods

authors： Seif el Nasr M,Nuglisch J,Krieglstein J

更新日期：1992-03-01 00:00:00